Several programs of the Department of Science and Technology are geared to encourage and develop interest among students, out-of-school youths, and young professionals in selected universities, colleges, and non-government organizations on technology-based entrepreneurship.

Under the combined programs called Small Enterprise Technology Upgrading Program, and DOST-Academe Technology-Based Enterprise Development (SETUP-DATBED) Program, the DOST through its National Capital Regional Office provides funds, facilities, and technologies to qualified schools and NGOs that offer tertiary science and technology courses, enterprise development programs, and youth projects.